Table 2.

SD-OCT cross-sectional analysis of most representative corneal lesions (scar, leukoma, or infiltrate) seen in eyes with herpetic stromal keratitis.

Lesion(s) parameter measured	Disease Activity			Type of Keratitis
	Active HSK No. Eyes (%) (n = 24)	Inactive HSK No. Eyes (%) (n = 29)	P- value	Non necrotizing keratitis No. Eyes (%) (n = 44 )	Necrotizing keratitis No. Eyes (%) (n = 9 )	P- value
Localization:
- Central (visual axis)	12 (50.0)	15 (51.7)	0.901	20 (45.4)	7 (77.7)	0.08
- Paracentral/peripheral	12 (50.0)	14 (48.3)	0.901	24 (54.6)	2 (22.3)	0.08
Density:
- Low (grade-I, < 33%)	7 (29.1)	10 (34.4)	0.464	17 (36.9)	0 (0.0)	0.040*
- Medium (grade-II, 34–66%)	11 (45.8)	13 (44.8)	0.942	21 (45.7)	3 (33.3)	0.956
- High (grade-III, > 67%)	6 (25.0)	6 (20.6)	0.777	8 (17.4)	6 (66.7)	0.010*
Depth:
- Superficial (< 150 µm)	7 (29.2)	10 (34.5)	0.683	17 (38.6)	0 (0.0)	0.025*
- Medial (150–350 µm)	11 (45.8)	13 (44.8)	0.942	21 (47.7)	3 (33.3)	0.434
- Deep (> 350 µm)	6 (25.0)	6 (20.7)	0.712	6 (13.6)	6 (66.7)	0.001*
Extension:
- Small (< 25% surface)	4 (16.6)	6 (20.6)	0.712	10 (22.7)	0 (0.0)	0.116
- Medium (25–45% surface)	13 (54.1)	21 (72.4)	0.172	30 (68.1)	4 (44.4)	0.18
- Large (> 45% surface)	7 (29.1)	2 (6.8)	0.033*	4 (9.0)	5 (55.5)	0.001*
SD-OCT, spectral-domain optical coherence tomography; HSK, herpetic stromal keratitis ${}^{*}$ P-value $<$ 0.05 was considered as statistically significant (Mann–Whitney U test for two independent samples).