Table 5.

Comparison of the amplitudes and latency times of rod responses from the Stivant-treated rabbits, saline-treated rabbits, and Avastin-treated rabbits

Groups		a-wave Amplitude	b-wave Amplitude	a-wave Latency Time	b-wave Latency Time
24 hours
Saline ( n * = 6)		–32.9 $\pm$ 7.8 µV	106.4 $\pm$ 12.7 µV	13.2 $\pm$ 0.1 ms	34.2 $\pm$ 0.3 ms
Avastin ( n = 28)		–35.8 $\pm$ 2.8 µV	114.8 $\pm$ 13.8 µV	13.9 $\pm$ 0. 7 ms	35.1 $\pm$ 1.3 ms
Stivant ( n = 14)		–36.1 $\pm$ 3.4 µV	99.1 $\pm$ 22.1 µV	13.9 $\pm$ 0.7 ms	32.3 $\pm$ 3.1 ms
P -value**	Stivant/saline	0.43	0.54	0.86	0.71
	Stivant/Avastin	0.73	0.21	0.79	0.69
48 hours
Saline ( n = 6)		–33.5 $\pm$ 8.8 µV	101.4 $\pm$ 19.2 µV	14.7 $\pm$ 0.7 ms	35.6 $\pm$ 1.2 ms
Avastin ( n = 28)		–34.7 $\pm$ 5.9 µV	100.8 $\pm$ 13.6 µV	14.7 $\pm$ 0.3 ms	37.3 $\pm$ 1 ms
Stivant ( n = 16)		–32.6 $\pm$ 5.9 µV	98.8 $\pm$ 11.9 µV	14.1 $\pm$ 0.5 ms	35.1 $\pm$ 3.4 ms
P -value**	Stivant/saline	0.38	0.44	0.88	0.90
	Stivant/Avastin	0.33	0.29	0.81	0.76
1 week
Saline ( n = 6)		–40 $\pm$ 8.1 µV	129.9 $\pm$ 27.2 µV	14.1 $\pm$ 0.6 ms	35.1 $\pm$ 1.6 ms
Avastin ( n = 28)		–32.9 $\pm$ 5.8 µV	106.5 $\pm$ 21.7 µV	14.3 $\pm$ 0.9 ms	32.5 $\pm$ 2.3 ms
Stivant ( n = 14)		–37.9 $\pm$ 9.2 µV	127.2 $\pm$ 38.3 µV	14.8 $\pm$ 0.7 ms	37.3 $\pm$ 1.9 ms
P -value**	Stivant/saline	0.19	0.33	0.87	0.53
	Stivant/Avastin	0.16	0.11	0.75	0.28
2 weeks
Saline ( n = 6)		–38.6 $\pm$ 8.4 µV	135.3 $\pm$ 28.3 µV	14.3 $\pm$ 0.7 ms	35.9 $\pm$ 1.5 ms
Avastin ( n = 28)		–44.5 $\pm$ 9.9 µV	134.4 $\pm$ 22.1 µV	13.6 $\pm$ 0.5 ms	35.1 $\pm$ 1.1 ms
Stivant ( n = 20)		–47.7 $\pm$ 9.5 µV	147.5 $\pm$ 21.5 µV	14.3 $\pm$ 0.6 ms	37.7 $\pm$ 1.1 ms
P -value**	Stivant/saline	0.14	0.18	0.94	0.72
	Stivant/Avastin	0.81	0.09	0.61	0.66
4 weeks
Saline ( n = 6)		–41.5 $\pm$ 13.3 µV	110.3 $\pm$ 20.5 µV	14.1 $\pm$ 0.6 ms	35.2 $\pm$ 2.1 ms
Avastin ( n = 28)		–42.6 $\pm$ 10.5 µV	110.4 $\pm$ 14.7 µV	14.2 $\pm$ 0.2 ms	33.2 $\pm$ 2.6 ms
Stivant ( n = 18)		–48.6 $\pm$ 14.1 µV	115.3 $\pm$ 30.1 µV	15.1 $\pm$ 0.5 ms	37 $\pm$ 2.1 ms
P -value**	Stivant/saline	0.14	0.68	0.88	0.67
	Stivant/Avastin	0.30	0.58	0.24	0.54
Data are expressed as mean $\pm$ SD *Number of the injected eyes in each group; **Based on generalized estimating equation (GEE) regression model Microvolts (µV); Milliseconds (ms)