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. 2020 Aug 11;8:782. doi: 10.3389/fcell.2020.00782

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Copyright © 2020 Zhang, Zhai, Zhang, Dai and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA m⁶A modifications regulate RNA metabolism. m⁶A is deposited onto nascent mRNAs by MTC. Then the m⁶A-modified mRNAs undergo AS by recruiting splicing factors to m⁶A sites or their flanking sequences. On the other hand, YTHDC1 and VIRMA can interact with the polyadenylation cleavage factors CPSF5 and CPSF6, thus regulating mRNA APA. Then, mRNAs can be recognized by YTHDC1 or FMRP and exported into the cytoplasm. Cytoplasmic m⁶A readers regulate mRNA stability (IGF2BPs), decay (YTHDF2), and translation (YTHDF1/3, YTHDC2, EIF3a, and METTL3) under normal and stress conditions.