FIG 4.

Sequence alignments with mammals. Structure-based sequence alignment of MHC-I molecules in rabbits and other representative mammals is shown (MHC I molecules covering the residues from positions 1 to 274 in RLA-A1). The coil and arrow above the sequence represent the α-helices and β-sheet, respectively. Residues in red indicate complete conservation, and residues boxed in blue represent 80% conservation, with the common amino acids shown in red. The residues at positions 53, 55, and 56 are shown in the black dotted box, and the residues at these three sites are more specific in rabbits; especially the residues at position 55 are completely conserved. The multiple sequence alignment was generated with ClustalX and ESPript.