Figure 4.

DMR localization on Chromosome 19. (a) DMRs on chromosome 19 were localized for sperm (left panel) and blastocyst (right panel) according to hypermethylated DMRs (blue) and hypomethylated DMRs (red) in APA relative to young. Increased DMR clustering is observed for cytoband 19p13.3. (b–d) All genes located on chromosome 19 (gray lines) were compared with DMR‐associated genes (red lines) in (b) sperm, (c) blastocyst, and (d) overlapping sperm blastocyst using kernel density estimates. Shaded areas around the lines signify the 95% confidence interval. Cytobands where the density of genes was significantly different between DMR‐associated genes and the genome are highlighted with gray boxes and include cytoband 19p13.3 for all comparisons