Table 1.
APA sperm and blastocyst DMRs
|
APA sperm (n = 3,405 DMRs) Paternal age: Young (28.5 ± 2.1 years) APA (54.5 ± 3.9 years) |
APA blastocyst (n = 3,997 DMRs) Paternal age: Young (32.7 ± 1.4 years) APA (52.7 ± 3.0 years) |
|||
|---|---|---|---|---|
| Hypermethylated | Hypomethylated | Hypermethylated | Hypomethylated | |
| Total DMRs | 1929 | 1,476 | 1729 | 2,268 |
| Significant CpGs in DMRs | 8,729 | 7,262 | 6,217 | 8,244 |
| Average CpGs per DMR | 4.5 (range 3–35) | 4.9 (range 3–40) | 3.6 (range 3–25) | 3.6 (range 3–14) |
| Average DMR window width | 211 bp (range 3–4069) | 370 bp (range 3–3792) | 550 bp (range 3–5432) | 544 bp (range 4–4033) |
| Total associated genes | 612 | 810 | 1,087 | 1,457 |
| Average genes per DMR | 0.32 | 0.55 | 0.63 | 0.64 |
| Total unique associated genes | 568 | 766 | 803 | 1,173 |
| DMRs not associated with a gene | 1,291 (67%) | 641 (43%) | 428 (25%) | 497 (22%) |