Table 4.
Neurodevelopmental disorder associations
| Disease | Overlapping genes | Fold enrichment (odds ratio) | OR 95% confidence interval | p‐value |
|---|---|---|---|---|
| APA sperm DMRs | ||||
| Autism spectrum disorder | 35 | 2.48 | 1.68–3.57 | 7.76E−06 |
| Schizophrenia | 19 | 2.31 | 1.35–3.77 | 1.57E−03 |
| Bipolar disorder | 63 | 1.93 | 1.45–2.53 | 8.24E−06 |
| APA blastocyst DMRs | ||||
| Autism spectrum disorder | 60 | 2.80 | 2.06–3.76 | 2.88E−10 |
| Schizophrenia | 40 | 3.40 | 2.30–4.94 | 2.42E−09 |
| Bipolar disorder | 91 | 1.71 | 1.35–2.16 | 1.17E−05 |
| APA sperm‐blastocyst directional overlapping DMRs | ||||
| Autism spectrum disorder | 10 | 4.34 | 2.03–8.28 | 1.94E−04 |
| Schizophrenia | 7 | 5.30 | 2.07–11.38 | 5.55E−04 |
| Bipolar disorder | 17 | 3.30 | 1.87–5.47 | 4.73E−05 |