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. 2020 Aug 17;11:4133. doi: 10.1038/s41467-020-17955-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Volcano plot of transcriptome profiles of control and Ctcf cKO sciatic nerves (n = 2 animals/genotype). Red and blue dots represent significantly downregulated and upregulated genes in Ctcf cKO nerves compared to the control, respectively (P < 0.05, fold-change > 1.5). b Heatmap of representative genes and their categories differentially expressed in control and Ctcf cKO sciatic nerves (n = 2 animals/genotype). c, d Bar plots of gene ontology analysis of genes c downregulated and d upregulated genes in Ctcf cKO sciatic nerves compared with control nerves. Each dot (connected by lines) represents the gene count of the corresponding biological function categories. n = 2 independent tissues/genotype. e qPCR analysis of genes related to SC development that are decreased (left) and increased (right) in Ctcf cKO sciatic nerves relative to control. f GSEA enrichment scores for myelin sheath (left) and lipid biosynthetic process (right) gene sets in control and Ctcf cKO sciatic nerves. g GSEA enrichment scores for cell-cycle gene sets in control and Ctcf cKO sciatic nerves. Data are presented as means ± SEM., ***P < 0.001, **P < 0.01, *P < 0.05, n = 3 animals/genotype; two-tailed unpaired Student’s t-test, P_(Prx) = 2.6e-05, P_(Mbp) = 4.9E-05, P_(Mpz) = 5.3E-06, P_(Hmgcr) = 0.0014, P_(Egr2) = 8.6E-05, P_(Itgb1) = 0.008, P_(Itgb3bp) = 0.00022, P_(Itgb5) = 0.0021, P_(Itgb8) = 0.00017, P_(Ccnd1) = 7.4E-05, P_(Ccng1) = 5.1E-05, P_(Ccno) = 0.0004, P_(Cdc7) = 6.4E-05, P_(Cdk5r2) = 1.6E-05, P_(Ccnb1) = 3.2E-05, P_(Notch1) = 0.00102, P_(Hes5) = 0.028, P_(Id2) = 0.23, P_(Id4) = 3.3E-05. Source data are provided as a Source Data file.