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. 2020 Aug 11;11:846. doi: 10.3389/fphys.2020.00846

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Copyright © 2020 Liu, Song, Ji, Liu, Li and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRDM16 inhibited AS through inactivation of the TGF-β signaling pathway. (A) The content of TC, TG, and HDL-C in peripheral blood in mice in each group as detected by biochemical indicators. (B) The changes of aortic plaques in AS mice as detected by HE staining (×200, scale bar: 50 μm). (C) The number of aortic thrombosis in AS mice as detected by ORO staining (×400, scale bar: 25 μm). (D) Positive rates of AS markers (ICAM-1 and VCAM-1) in the aorta of AS mice as detected by IHC (×400). *p < 0.05 compared with mice treated with DMSO, ^#p < 0.05 compared with mice treated with oe-PRDM16 NC. The measurement data were expressed as mean ± standard deviation, and analyzed by independent-sample t-test, n = 15.