Table 2.
Treatment and prognostication
| Characteristics | Conservative oxygen (n = 87) | Usual oxygen (n = 79) | P value |
|---|---|---|---|
| Pre-randomisation treatment | |||
| Drugs given during resuscitation—no. (%) | |||
| Adrenaline | 60 (69%) | 60 (75.9%) | 0.32 |
| Amiodarone | 24 (27.6%) | 24 (30.4%) | 0.69 |
| Vasopressin | 0 (0%) | 0 (0%) | 1.00 |
| None given | 24 (27.6%) | 17 (21.5%) | 0.37 |
| Unknown | 2 (2.3%) | 1 (1.3%) | 1.00 |
| Post-randomisation oxygen therapy | |||
| Proportion of hours SpO2 ≥ 97% | 0.391 (0.254) | 0.529 (0.257) | 0.001 |
| Number of hours SpO2 ≥ 97% | 26 [13–45] | 35 [19–70] | 0.05 |
| Proportion of hours SpO2 < 88% | 0 [0–0.02] | 0 [0–0.01] | 0.37 |
| Number of hours SpO2 < 88% | 0 [0–2] | 0 [0–1] | 0.4 |
| Proportion of patients with at least one PaO2 recording less than 60 mmHg | 31 (87%) | 15/79 (19%) | 0.02 |
| Proportion of patients with at least one PaO2 recording greater than 100 mmHg | 51 (59%) | 60 (76%) | 0.02 |
| Proportion of hours FiO2 0.21 | 0.37 [0.08–0.61] | 0 [0–0.12] | < 0.0001 |
| Number of hours FiO2 0.21 | 25 [8–43] | 0 [0–6] | < 0.0001 |
| Other post-randomisation treatment | |||
| Targeted temperature management—no. (%) | 72 (82.8%) | 65 (82.3%) | 0.94 |
| Target 32–34 °C—n/N (%) | 3/72 (4.2%) | 4/65 (6.2%) | 0.79 |
| Target 36 °C—n/N (%) | 51/72 (70.8%) | 43/65 (66.2%) | |
| Other target—n/N (%) | 18/72 (25.0%) | 18/65 (27.7%) | |
| Neuroprognostic tests performeda—no. (%) | |||
| Somatosensory evoked potentials (SSEPs) | 6 (7%) | 8 (10.1%) | 0.45 |
| Neurone specific enolase (NSE) | 0 (0%) | 0 (0%) | 1.00 |
| Electroencephalogram (EEG) | 8 (9.2%) | 14 (17.7%) | 0.11 |
| CT brain | 39 (44.8%) | 26 (32.9%) | 0.12 |
| MRI brain | 5 (5.7%) | 10 (12.7%) | 0.12 |
aSSEP and NSE data were available for 86 conservative oxygen patients and 78 usual oxygen patients