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Mechanisms of P450-related drug-drug interactions
| Perpetrator drug | Effect on victim drug |
|---|---|
| Inducer | Increased metabolism, lack of efficacy |
| Inducer | Increased bioactivation via a minor pathway |
| Competitive inhibitor | Decreased metabolism, toxicity due to elevated level of drug |
| Irreversible inhibitor | Decreased metabolism, toxicity due to elevated level of drug |
| Allosteric activator | Same as inducer |
