TABLE 1.
Genes exhibiting significant (FDR-adjusted P-value < 0.1) maternal immune activation-by-sex interaction effect.
| Gene symbol | P-value | aCON Fe-CON Ma | MPA Fe-MPA Ma | CON Fe-MPA Fe | CON Ma-MPA Ma | CON Fe-MPA Ma | CON Ma-MPA Fe |
| RGS16 | <5E-11 | –3.25 | 2.24 | –2.44 | 3.06 | –0.19 | 0.81 |
| CGA | <5E-11 | –5.86 | 0.36 | 0.27 | 6.49 | 0.63 | 6.13 |
| POMC | <5E-11 | –2.79 | 0.33 | 0.06 | 3.19 | 0.39 | 2.86 |
| GPX3 | <5E-11 | –1.19 | 0.99 | –0.37 | 1.81 | 0.63 | 0.82 |
| RELN | <5E-11 | –0.17 | 0.66 | –0.74 | 0.09 | –0.08 | –0.57 |
| VIPR2 | <5E-11 | –1.17 | 1.04 | –1.03 | 1.18 | 0.00 | 0.14 |
| ANKRD34C | <5E-11 | –0.77 | 0.87 | –0.71 | 0.93 | 0.16 | 0.06 |
| GBP1 | <5E-11 | 0.92 | –0.32 | –0.75 | –1.99 | –1.07 | –1.66 |
| GRM4 | <5E-11 | –0.97 | 0.91 | –0.70 | 1.17 | 0.20 | 0.27 |
| CCDC136 | 5.3E-09 | –0.39 | 0.43 | –0.15 | 0.67 | 0.29 | 0.24 |
| SLC17A6 | 1.1E-08 | –0.40 | 0.54 | –0.16 | 0.77 | 0.37 | 0.23 |
| BTBD11 | 4.4E-08 | –0.62 | 0.45 | –0.40 | 0.67 | 0.05 | 0.22 |
| TTR | 5.0E-08 | –0.47 | 0.24 | 0.29 | 1.00 | 0.53 | 0.76 |
| CACNA2D3 | 4.8E-07 | –0.50 | 0.44 | –0.26 | 0.68 | 0.18 | 0.23 |
| CRHR2 | 2.8E-06 | –0.24 | 1.09 | –0.36 | 0.97 | 0.74 | –0.12 |
| NDNF | 2.8E-06 | –0.09 | 0.88 | –0.70 | 0.27 | 0.18 | –0.61 |
| CXCL12 | 6.2E-06 | –0.41 | –0.01 | –0.10 | 0.29 | –0.11 | 0.30 |
| USP43 | 6.4E-06 | –0.64 | 0.43 | –0.34 | 0.72 | 0.09 | 0.29 |
| CCDC17 | 7.1E-06 | 0.74 | –0.30 | 0.26 | –0.40 | 0.03 | 0.12 |
| KCNIP4 | 7.2E-06 | –0.01 | 0.35 | 0.11 | 0.47 | 0.46 | 0.11 |
| CAMK2N2 | 9.6E-06 | –0.24 | 0.16 | –0.23 | 0.18 | –0.07 | 0.01 |
| ALDH1A2 | 1.4E-05 | –1.35 | 0.50 | 0.48 | 2.32 | 0.98 | 1.83 |
| GRP | 1.5E-05 | –0.89 | 0.73 | –0.61 | 1.02 | 0.12 | 0.28 |
| PENK | 1.6E-05 | –0.10 | 0.46 | –0.04 | 0.51 | 0.42 | 0.06 |
| SYT12 | 2.9E-05 | –0.16 | 0.32 | –0.11 | 0.37 | 0.21 | 0.05 |
| PTH1R | 3.7E-05 | –0.33 | 0.52 | –0.51 | 0.34 | 0.01 | –0.18 |
| HBB | 6.7E-05 | –0.48 | 0.10 | 0.12 | 0.70 | 0.22 | 0.60 |
| ESYT1 | 8.5E-05 | –0.47 | 0.29 | –0.27 | 0.49 | 0.02 | 0.20 |
| EFHD1 | 9.6E-05 | –0.31 | 0.42 | –0.37 | 0.36 | 0.05 | –0.06 |
| BHLHE22 | 1.0E-04 | 0.06 | –0.59 | 0.05 | –0.61 | –0.55 | –0.01 |
| ZFP37 | 1.2E-04 | 0.60 | 0.60 | –0.19 | –0.18 | 0.41 | –0.78 |
| SLC2A2 | 1.5E-04 | 0.08 | 0.50 | –0.04 | 0.38 | 0.46 | –0.12 |
| THRSP | 3.1E-04 | –0.72 | 0.51 | –1.24 | –0.01 | –0.73 | –0.52 |
| NR4A3 | 3.3E-04 | –0.12 | –0.01 | –0.08 | 0.04 | –0.08 | 0.04 |
| LOC396781 | 4.4E-04 | –0.75 | 1.36 | –5.38 | –3.27 | –4.01 | –4.63 |
| C1QTNF1 | 4.5E-04 | –0.37 | 0.32 | –0.23 | 0.46 | 0.09 | 0.14 |
| RAB27A | 5.6E-04 | –0.97 | 0.05 | –0.25 | 0.77 | –0.20 | 0.72 |
| NTS | 7.9E-04 | –1.43 | 2.81 | –1.78 | 2.47 | 1.03 | –0.35 |
| GVIN1 | 7.9E-04 | 0.80 | –0.41 | –1.01 | –2.22 | –1.42 | –1.81 |
| SSTR1 | 8.6E-04 | 0.11 | –0.38 | 0.16 | –0.33 | –0.22 | 0.05 |
| CCDC9B | 8.8E-04 | –0.24 | 0.35 | –0.34 | 0.25 | 0.01 | –0.10 |
| CCDC33 | 1.4E-03 | 0.48 | –0.39 | 0.49 | –0.38 | 0.10 | 0.01 |
| CCDC162P | 1.4E-03 | 0.11 | –0.48 | 0.36 | –0.23 | –0.12 | 0.25 |
| PTH | 1.4E-03 | –0.03 | 0.29 | –0.68 | –0.36 | –0.39 | –0.65 |
| SYNPO2L | 1.5E-03 | –0.28 | 0.59 | –0.44 | 0.43 | 0.15 | –0.16 |
| CHGB | 1.8E-03 | –0.58 | –0.16 | 0.37 | 0.79 | 0.21 | 0.96 |
aLog2[fold change] between two maternal immune activation-sex groups: MPA, PRRSV-induced maternal immune activation; CON, control; Fe, females; Ma, males.