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. 2020 Jun 30;45(3):e39. doi: 10.5395/rde.2020.45.e39

Table 1. Effect of irrigation sequences on dentin composition.

No. Author Sample type Groups Outcome measure Main findings
Irrigation sequence Duration (min)*
1 Doğan et al. [33] Root canal dentin 17% EDTA/2.5% NaOCl 15-? Calcium/phosphate ratio EDTA/NaOCl altered the Ca/P ratio and Mg level significantly when compared to the control group
17% EDTA/saline 15-?
2.5% NaOCl ?
Saline (control) ?
2 Sayin et al. [34] Root canal dentin 2.5% NaOCl 1, 5 Calcium loss EDTA and EDTA/NaOCl treatment for 1 and 5 min showed significantly more calcium ion loss
17% EDTA 1, 5
17% EDTA/2.5% NaOCl 1-1, 5-5
Distilled water (control) 1, 5
3 Wang et al. [35] Root canal dentin Control Element distribution (EDS) Reduced Ca and P values in NaOCl/EDTA/NaOCl group
3% NaOCl/8% EDTA 5-2
3% NaOCl/8% EDTA/3% NaOCl 2-2-1
5% NaOCl/17% EDTA 2-2
5% NaOCl/17% EDTA/5% NaOCl 2-2-1
5% NaOCl/17% EDTA/5% NaOCl 5-5-5
4 Zhang et al. [36] Dentin powder Control–no treatment - Apatite/collagen ratio (FTIR) EDTA decreased the apatite/collagen ratio 5.25% NaOCl for more than 60 min showed a significant increase in apatite/collagen ratio and decrease in flexural strength
17% EDTA 2 - Flexural strength
1.3% NaOCl/17% EDTA 10, 20, 30, 60, 120, 180, 240-2
5.25% NaOCl/17% EDTA 10, 20, 30, 60, 120, 180, 240-2
5 Zhang et al. [37] Dentin powder Control–no treatment - Apatite/collagen ratio - Significant increase in apatite/collagen ratio with time and concentration of NaOCl
17% EDTA 2 - Collagen degradation (FTIR) - Tunneling erosion pattern with subsurface erosion with 5.25% NaOCl/EDTA
1.3% NaOCl 10, 20, 30, 60, 120, 180, 240
1.3% NaOCl/17% EDTA 10, 20, 30, 60, 120, 180, 240-2
5.25% NaOCl 10, 20, 30, 60, 120, 180, 240
5.25% NaOCl/17% EDTA 10, 20, 30, 60, 120, 180, 240-2

EDTA, ethylenediaminetetraacetic acid; NaOCl, sodium hypochlorite; Ca, calcium; P, phosphorus; EDS, energy dispersive spectroscopy; FTIR, Fourier-transform infrared spectroscopy.

*? represent unknown.

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