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. 2020 Aug 11;11:1945. doi: 10.3389/fimmu.2020.01945

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Copyright © 2020 Bi and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional regulation of NK cell development and maturation. Multiple transcriptional factors mediate regulation at distinct stages during NK cell development and maturation. E4BP4, TCF1 and ID2 are essential for NK cell lineage commitment. T-BET, EOMES, TOX, PRDM1, GATA3, ZEB2, and SMAD4 are critical for NK cell maturation. The discrepancy of FOXO1 in NK cell maturation needs further confirmation.