Table 1. Cutaneous adverse drug reactions mechanisms summary.
| Type A - Augmented | Type B - Bizarre | ||||
|---|---|---|---|---|---|
| Predictable (example:
overdose) |
Non-immunological
(example: intolerance) |
Immunological | |||
| Type I: IgE | Type II: IgG
cytotoxic |
Type III: immune
complexes |
Type IV: delayed
hypersensitivity |
||
| Urticaria/Angioedema | Hemolytic
anemia |
Vasculitis | Delayed | ||
| IVa: ACD | |||||
| IVb: DiHS/DRESS | |||||
| IVc: SJS-TEN, morbilliform | |||||
| IVd: AGEP | |||||
ACD, allergic contact dermatitis; AGEP, acute generalized exanthematous pustulosis; DiHS, drug-induced hypersensitivity syndrome; DRESS, drug reaction with eosinophilia and systemic symptoms; SJS-TEN, Stevens–Johnson syndrome–toxic epidermal necrolysis 4. Adapted with permission from Noguera-Morel et al. 1.