Table 4. Medication causes of SJS-TEN with strongly predictive (100%) HLA associations ³⁵.

Medication	Population	HLA type	Interpretation of positive result
Allopurinol	Han Chinese and European	B*5801	Increased risk of SJS-TEN, do not use in naïve patients, can be considered in patients without reaction after more than 3 months
Carbamazepine	Han Chinese, Thai, Malaysian, Indian, Singaporean, and Vietnamese	B*1502	Increased risk of SJS-TEN, do not use CBZ or ox-CBZ in naïve patients, can consider using if no reaction after more than 3 months treatment
	European, Japanese, and Korean	B*3101

CBZ, carbamazepine; HLA, human leukocyte antigen; ox-CBZ, oxcarbazepine; SJS-TEN, Stevens–Johnson syndrome – toxic epidermal necrolysis. ³⁵. Adapted with permission from Peter et al. ¹⁹.