Skip to main content
. 2020 Aug 1;21(15):5515. doi: 10.3390/ijms21155515

Figure 2.

Figure 2

IMQ-induced psoriasis-like inflammation is significantly more severe in IDO2 KO mice. (a) Macroscopic phenotypic representation of the left ear in WT and IDO2 KO mice treated with vehicle or IMQ for 7 days. (b) Erythema, scaling, and thickness of the ear were evaluated daily (0 = none, 1 = slight, 2 = moderate, 3 = marked, 4 = very marked). Data are representative of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 when comparing IDO2 KO-IMQ to WT-IMQ (two-way ANOVA). Control groups, n = 4; IMQ-treated groups, n = 7. (c) Hematoxylin and eosin staining of the ear in WT and IDO2 KO mice treated with vehicle or IMQ for 7 days. Scale bar = 200 µm. (d) Microscopic evaluation of epidermal hyperplasia after 7 days of treatment. Data are presented as mean ± SEM. *** p < 0.001 (one-way ANOVA). Control groups, n = 6–7; IMQ-treated groups, n = 9. WT: wild type, IDO: indoleamine 2,3-dioxygenase, Con: control, IMQ: imiquimod, KO: knockout.