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. 2020 Aug 1;21(15):5515. doi: 10.3390/ijms21155515

Figure 5.

Figure 5

The concentration of tryptophan metabolites is higher in IMQ-treated IDO2 KO mice than WT mice. The concentration of tryptophan, kynurenine, kynurenic acid, anthranilic acid, and 3-HAA in the ears of WT and IDO2 KO mice with vehicle or IMQ treatment for 7 days were measured by high performance liquid chromatography. Data are presented as mean ± SEM. * p < 0.05, *** p < 0.001 (one-way ANOVA). Control groups, n = 4; IMQ-treated groups, n = 7. 3-HAA: 3-hydroxy anthranilic acid, ND: not-detected, WT: wild type, IDO: indoleamine 2,3-dioxygenase, Con: control, IMQ: imiquimod, KO: knockout.