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(A) Schematic representation of neuromyelitis optica spectrum disorder (NMOSD) pathogenesis: currently available treatments and their targets are reported. ADCC, antibody-dependent cell-mediated cytotoxicity; AQP4-IgG, anti-aquaporin-4 immunoglobulin G; NK, natural killer; MMF, mycophenolate mofetil; aza, azathioprine. (B) Allogeneic HSCT rationale and immunological implications.
