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. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transcriptome analysis of the effect of chemical exposure on gene expression in hESC-derived spheres. (A) Summary of the number and (B) functional annotation of differentially expressed genes in hESC-derived spheres after exposure to 1 μM TMD, 0.01 μM BDE47, 0.1 μM BPA, and 0.01 μM 4OH-PCB187. (C) Canonical pathway analysis of differentially expressed genes generated using the knowledge-based functional analysis software Ingenuity Pathways Analysis (IPA). (D) Expression of enriched genes involved in the synaptogenesis signaling pathway.