Table 1.
Transcription factors with significantly increased activity evaluated by expression of their targets in MSC-based cell sheets compared to monolayer MSC. TF—transcription factor; entries ranked by Q-value and p-value; TFs with 4 and more overlapping targets presented.
| Rank | TF | Overlapped Genes N | List of Overlapped Genes |
|---|---|---|---|
| 1 | SP1 | 28 | C4A, AGTR1, EDNRB, AGT, PPL, MMP2, TNC, EGR1, LSP1, CCND2, TNFSF10, MME, FBLN1, CYP27A1, SOX9, COMP, SLC39A8, COL18A1, C4B, SREBF1, HGF, TCN2, ISG20, APOE, SOD2, CYP19A1, PTN, CHI3L1 |
| 2 | NFKB1 | 22 | EGR1, BGN, CYP19A1, PTGFR, TNC, SOD2, ADORA1, CXCL12, TNFSF13B, MMP2, CD74, FGF7, IRF4, AGT, SLC25A27, PLA2G2A, CCND2, BCL2L11, IRF7, VCAM1, A2M, TNFSF10 |
| 3 | RELA | 20 | IRF7, EGR1, FGF7, ADORA1, CXCL12, MMP2, SLC25A27, SOD2, VCAM1, BCL2L11, TNFSF10, PLA2G2A, TNC, CD74, CYP19A1, CCND2, PTGFR, AGT, BGN, IRF4 |
| 4 | FOXO3 | 8 | BCL6, TXNIP, TNFSF10, BCL2L11, CCND2, VEGFA, CDKN2B, VEGFB |
| 5 | USF1 | 8 | FMO3, TCN2, AGT, CYP19A1, SLC1A3,LIPC, CTSD, ISG20 |
| 6 | SREBF1 | 5 | LRP1, ACACB, LDLR, FASN, CIC |
| 7 | STAT3 | 10 | CCND2, CFB, PROS1, HGF, MMP2, CYP19A1, A2M, CHI3L1, DIRAS3, BCL6 |
| 8 | HIF1A | 12 | TGFB3, TLR6, VEGFA, ARNT, TIMP2, SOCS1, VEGFB, MMP2, CXCL12, EDNRB, ACE, AGTR1 |
| 9 | FOXO1 | 4 | TNFSF10, EGR1, ANGPT2, TXNIP |
| 10 | JUN | 10 | DCN, VCAM1, CYP19A1, MMP2, SOD2, PTN, TNC, MGP, FGF7, LBP |
| 11 | DNMT1 | 4 | ESR1, IL32, CDKN2B, VEGFA |
| 12 | SP3 | 8 | FBLN1, HGF, SLC1A3, ACE, TCN2, MMP2, AGTR1, CYP27A1 |
| 13 | CREB1 | 7 | NR4A3, AQP3, BCL2L11, BDKRB2, SOX9, MMP2, CYP19A1 |
| 14 | MYC | 7 | VEGFA, JUNB, HLA-B, TFAP4, SHMT1, MST1, BCL2 |
| 15 | ESR1 | 6 | ESR1, BCL2, VEGFA, ZEB1, CEBPB, JUNB |
| 16 | ETS2 | 4 | EGR1, ANGPT2, MMP2, TNC |
| 17 | WT1 | 5 | WTAP, BCL2, VEGFA, VEGFB, JUNB |
| 18 | ATF4 | 4 | IRF7, HRK, DDIT4, APOE |
| 19 | PPARA | 4 | TXNIP, SOD2, G0S2, CD36 |
| 20 | SPI1 | 5 | JCHAIN, BCL6, MME, CTSS, CTSK |
| 21 | MYCN | 4 | EFNB3, CTSD, MXI1, CLU |
| 22 | USF2 | 4 | TCN2, CTSD, CYP19A1, LIPC |
| 23 | HDAC1 | 5 | HLA-DRA, EGR1, CCND2, TXNIP, SFRP1 |
| 24 | STAT1 | 4 | UPP1, XAF1, STAT2, MUC1 |
| 25 | BRCA1 | 4 | ESR1, IRF9, VEGFA, DDIT3 |
| 26 | TP53 | 8 | BDKRB2, GPNMB, PDGFRB, AQP3, EGR1, PMAIP1, CTSD, MMP2 |
| 27 | ETS1 | 5 | DUSP6, ANGPT2, EGR1, TMEM158, TNC |
| 28 | YY1 | 5 | SAP30, VWF, LSS, VEGFB, LDLR |
| 29 | BRCA1 | 4 | EGR1, CTSD, IRF7, CYP19A1 |