(b)

		Overall Survival (Discovery)		Overall Survival (Validation)
Overall n/Events		1675/538		2165/689
		HR (95% CI)	p	HR (95% CI)	p
Gender	Male	[1]		[1]
	Female	0.89 (0.75–1.05)	0.16	1.27 (1.09–1.49)	0.003
Age Category	<60	[1]		[1]
	60–69	1.24 (0.94–1.62)	0.13	1.31 (1.00–1.72)	0.047
	70–79	1.45 (1.10–1.90)	0.007	1.84 (1.43–2.36)	<0.0001
	>80	2.84 (2.14–3.77)	<0.0001	3.40 (2.63–4.39)	<0.0001
Stage at Diagnosis	I	[1]		[1]
	II	1.53 (1.10–2.12)	0.01	1.81 (1.38–2.37)	<0.0001
	III	2.73 (2.01–3.69)	<0.0001	2.70 (2.08–3.52)	<0.0001
	IV	13.28 (9.81–17.98)	<0.0001	13.33 (10.26–17.31)	<0.0001
Grade	G1-G2	[1]		[1]
	G3-G4	1.27 (1.06–1.52)	0.01	1.85 (1.57–2.18)	<0.0001
Alcohol Consumption (g/day)	no intake	[1]		[1]
	0.1–6.1	0.69 (0.53–0.88)	0.003	0.79 (0.64–0.98)	0.03
	6.1–15.6	0.70 (0.54–0.91)	0.007	0.76 (0.61–0.95)	0.02
	15.6–32.6	0.67 (0.52–0.86)	0.002	0.88 (0.70–1.09)	0.24
	≥32.6	0.74 (0.58–0.96)	0.02	0.93 (0.73–1.18)	0.54
BMI (kg/m2)	18.5–25>	[1]		[1]
	<18.5	1.72 (1.075–2.75)	0.02	1.18 (0.71–1.95)	0.53
	25–30>	0.77 (0.64–0.93)	0.007	0.76 (0.65–0.90)	0.002
	≥30	0.71 (0.56–0.91)	0.007	0.78 (0.63–0.96)	0.02

Abbreviations: HR: hazard ratio; CI: confidence interval; BMI: body mass index.