Table 4.
Fetal incidence of ventricular septal defects (VSDs) in control Sprague Dawley rats after enhanced cardiac evaluations
| Study | Ventricular septal defects (%) |
|---|---|
| Haring (1965)a | 3.2 |
| Haring (1966)a | 2.8 |
| Inomata and Yasuda (1971)b | 5.2 |
| Inomata and Yasuda (1971)b | 3.6 |
| Solomon et al. (1997) | 2.0 |
| Current studyc | 2.4 |
a
Hearts were embedded in paraffin, serially sectioned and examined by light microscopy.
b
Examined by a combination of Wilson freehand razor sections plus microdissection of the cardiac outflow tract.
c
Examined by fresh dissection.