Table 6.
Comparison of various studies investigating TCE‐induced cardiac defects in Sprague Dawley rats
| Study | Route | TCE exposure | Duration | Number of females/group | Maternal toxicity | Exam method | Abnormal heartsa |
|---|---|---|---|---|---|---|---|
| Fisher et al. (2001) | Oral gavage | 500 mg/kg/day | GD 6–15 | 20 | None observed | Johnson | 4.5% (13/290) |
| 0 (soybean oil) | 25 | 6.5% (24/367) | |||||
| Johnson et al. (2003) | Drinking water | 0 ppm | GD 1–21 | 55 | Not assessed | Johnson | 2.2% (13/606) |
| 0.0025 ppm (0.0005 mg/kg/day) | 12 | 0 | |||||
| 0.25 ppm (0.05 mg/kg/day) | 9 | 4.5% (5/110) | |||||
| 1.5 ppm (0.22 mg/kg/day) | 13 | 5.0% (9/181) | |||||
| 1,100 ppm (129 mg/kg/day) | 9 | 10.5% (7/308) | |||||
| Present study | Drinking water | 0 ppm | GD 1–21 | 24 | None observed | Enhanced Stuckhardt and Poppe | 2.3% (7/308) |
| 0.25 ppm (0.04 mg/kg/day) | 23 | 1.5% (4/275) | |||||
| 1.5 ppm (0.21 mg/kg/day) | 24 | 1.6% (5/321) | |||||
| 500 ppm (58 mg/kg/day) | 24 | 3.9% (13/330) | |||||
| 1,000 ppm (113.5 mg/kg/day) | 24 | 3.5% (12/342) | |||||
| Carney et al. (2006) | Inhalation | 0 ppm | GD 6–20 (6 hr/day; 7 day/week) | 22 | None observed | Stuckhardt and Poppe | 0 |
| 50 ppm | 22 | None observed | 0 | ||||
| 150 ppm | 22 | None observed | 0 | ||||
| 600 ppm | 22 | 22% decrease in body weight gain GD 6–9 | 0 |
Abbreviations: GD, gestational day; TCE, trichloroethylene.
a
Values presented are percent overall incidence (incidence data).