Table 7.
Comparison of peak plasma concentration of TCE and TCA after various exposures
| Peak (AUC) concentration (μg/mL or mg·hr/L) | ||||||
|---|---|---|---|---|---|---|
| TCE | TCA | |||||
| Exposure Route | Drinking watera | Drinking waterb | Inhalationb | Gavageb | Gavagec | Gavagec |
| TCE/TCA | 0.25–1,000 ppm | 350 ppm | 600 ppm, 4 hr | 2.3 mg/kg | 591 mg/kg | 98 mg/kg |
| TCE blood | ND | ND | 24 (1,864) | 0.26 (0.72) | 33 | — |
| TCA plasma | 1.1–1.2 | 2.7 (585) | 13 (5,201) | 0.70 (106) | 25 | 201 |
Abbreviations: AUC, area under the curve; TCA, trichloroacetic acid; TCE, trichloroethylene.
a
Current study, ND = Below LOD (50 ng/mL); TCA detected only 500 and 1,000 ppm, not at 0.25 and 1.5 ppm.
b
Fisher et al. (1989); TCE and TCA measured in pregnant GD21 SD rats following dosing at 5 days/week for 3 weeks.
c
Larson and Bull (1992); TCE and TCA measured after single dose to adult male rats; TCE C max estimated from graphical data.