Table 2.

Therapeutic agents targeting TAMs for OS treatment.

Agent	Mechanism	Phase	Ref.
All trans retinoic acid	Reduces polarization of M2-like	Pre-clinical	[8]
Mifamurtide Esculetin	Induces M1-like activation Inhibits TAMs differentiation	3 Pre-clinical	[145] [150]
Zoledronate	Polarizes TAMs to M1-like	3	[151]
Natalizumab	Interferes cross-talk between cancer cells and TAMs	NCT03811886	[157]
Nivolumab	mAbs anti-PD-1	NCT02304458	[158]
Pembrolizumab	mAbs anti-PD-1	NCT02301039	[158]