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. 2020 Aug 11;10:1579. doi: 10.3389/fonc.2020.01579

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Copyright © 2020 Wang, Yang, Liu, Xu, Zhang, Jiang, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ceRNA network construction and protein–protein interaction network. (A) A lncRNA-miRNA-mRNA ceRNA network was constructed by 33 lncRNAs, 21 miRNAs, and 135 mRNAs. (B) A PPI network was constructed based on the STRING database. The rectangle represents microRNAs, the circle represents mRNAs and the triangle represents lncRNAs; the red represents up-regulation in IS-high and the green represents down-regulation in IS-high; the size of the dot represents the regulatory capacity of the mRNA, and larger points indicate stronger regulatory capability. ceRNA, competing endogenous RNAs; PPI: protein–protein interaction.