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Plasma urate levels and excretion of urate in PO- and adenine-induced hyperuricemia mice. (a) Plasma uric acid levels after administration; (b) 24 h Cur; (c) Urine volume. Nor, normal control group; Mod, PO-induced hyperuricemia group; Ben-50, positive control benzbromarone group. Values represent the mean ± SD of determinations (n = 12); * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. hyperuricemia group.
