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The dual role of PACAP on MNs and glial cells. PACAP induced neuroinflammation by promoting transition from amoeboid to hypertrophic microglia morphology in SOD1(G93A) mice. On the other hand, it promoted axonal regeneration process after nerve injury and protected rat motor neurons in culture against glutamate-induced excitotoxicity and iPSC-derived motor neurons from apoptosis.
