Hepatic levels of phosphorylated insulin receptor tyrosine 972 (pIRTyr972), phosphorylated insulin receptor-β tyrosine 1146 (pIRβTyr1146), total 5’ AMP-activated protein kinase (AMPK), phosphorylated AMPK, total Akt, and phosphorylated Akt in lean, HFD-, and HFD + PSO-treated mice. (A) Representative western blots for pIRTyr972, pIRβTyr114, and β-actin. (B) Quantitation of the hepatic levels of pIRTyr972. (C) Quantitation of the hepatic levels of pIRβTyr114. (D) Representative western blots for pAMPK, total AMPK, pAkt, total Akt, and β-actin. (E) Quantitation of the hepatic levels of pAMPK/total AMPK. (F) Quantitation of the hepatic levels of pAkt/total Akt. * = different p < 0.05 from corresponding value in lean mice. # = different p < 0.05 from corresponding value in HFD mice. n = 6/group.