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. 2020 Aug 11;11:837. doi: 10.3389/fgene.2020.00837

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Copyright © 2020 Botero, Monk, Rodríguez Cubillos, Rodríguez Cubillos, Restrepo, Bernal-Galeano, Reyes, González Barrios, Palsson, Restrepo and Bernal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reconstructed metabolic map of xanthan biosynthesis in Xpm. Reactions belonging to xanthan biosynthesis pathway are shown to the left side: gumD,M,H,K,I,F,G,L and gumBCEJ. The carbohydrate utilization pathways are connected with the xanthan biosynthesis reaction by three branches (middle part of the graph). PGMT, phosphoglucomutase; GALUi, UTP-glucose-1-phosphate uridylyltransferase; UDPGD, UDPglucose 6-dehydrogenase; MAN6PI, mannose-6-phosphate isomerase; MPPM, D-mannose 6-phosphate 1,6-phosphomutase; MAN1PT2, mannose-1-phosphate guanylyltransferase; DXPS, 1-deoxy-D-xylulose 5-phosphate synthase; DXPRIi, 1-deoxy-D-xylulose reductoisomerase; CMS, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; CDPMEK, 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase; MCS, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; MECDPDH2, 2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase; DMPPS, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase; IDS1, isopentenyl-diphosphate synthase; DMATT, dimethylallyltranstransferase; FPPSh, farnesyl pyrophosphate synthase; MNXR55990, undecaprenyl diphosphate synthase. Carbohydrate utilization pathways: Entner–Doudoroff (ED), pentose-phosphate (PP), and Embden–Meyerhof–Parnas (EMP). Constructed in Escher (King et al., 2015).