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. 2020 Jul 31;21(15):5495. doi: 10.3390/ijms21155495

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of miR-449a on the migration and tumor sphere formation. C666-1 cells were transfected with pre-miR-449a. (A) Transwell migration of transfected cells. Upper panel: images of the migrated cells. Lower panel: quantitative analysis of the cells migration. (B) Tumor sphere formation assay. Upper panel: images of tumor spheres in culture well of ultralow attachment plate. Lower panel: quantitative analysis of spheroid number in pre-miR449a transfected cells. (C) Size distribution profile of tumor spheres. At least three independent experiments were carried out. * p < 0.05; ** p < 0.01 compared the control group.