Table 1.
Studies of inflammatory biomarkers measured in blood and breast cancer risk, published January 2014 to April 2020 in PubMed.
| Unique Study # |
Citation # | Author, Year | PMID | Population, Sample Size | Study Design | Biomarkers |
|---|---|---|---|---|---|---|
| 1 | 25 | Agnoli, 2017 | 28983080 | 351 cases and 351 controls; ages 35–69 years at baseline (1992–1997); 14.9 years of follow-up; Italy | Nested case-control in EPIC-Varese cohort | CRP, TNF-α, IL-6, leptin, adiponectin |
| 2 | 26 | Allin, 2016 | 27194008 | 822 cases (n = 44,715); ages 48–67 at baseline (2003–2012); median follow-up of 4.8 years; Denmark | Population-based prospective cohort | hsCRP, fibrinogen, leukocyte count, inflammatory score |
| 3 | 27 | Berger, 2018 | 30018397 | 167 cases and 249 controls; mean age of 52.8 years at baseline (1990–2008); 15.5 years of follow-up; Italy and Sweden | Nested case-control in EPIC-Italy and NSHDS | Inflammatory score |
| 4 | 28 | Busch, 2018 | 29614476 | 394/4,328 invasive and 100/1049 in situ cases (n = 14,375/130,844) for CRP/WBC count; 50–79 years at baseline (1993–1998); 18.6 years of follow-up; USA | Prospective cohort study in the Women’s Health Initiative | hsCRP, WBC count |
| 5 | 23 | Chan, 2015 | 26224798 | 12 prospective studies involving a total of 3,522 cases (n = 69,610); published 2005–2015 | Meta-analysis | CRP |
| 6 | 29 | Dias, 2016 | 27391324 | 446 cases and 885 controls; ages 55–74 years at baseline (1991–1996); followed through December, 2010; Sweden | Nested case-control in Malmö Diet and Cancer cohort | Ox-LDL, IL-1β, IL-6, IL-8, TNF-α, WBC count, lymphocyte count, neutrophil count |
| 7 | 30 | Dossus, 2014 | 24504436 | 549 cases and 1,040 controls; mean age of 57.7/57.4 years (cases/controls) at baseline (1995–1999); followed through July, 2005; France | Nested case-control in French E3N cohort | CRP |
| 8 | 31 | Frydenberg, 2016 | 26740213 | 192 cases (n = 8,130); mean age of 49.8 years at baseline (1994–2008); 14.6 years of follow-up; Norway | EBBA-Life sub-study in the Tromsø population-based prospective cohort | hsCRP and WBC count |
| 9 | 32 | Gunter, 2015 | 26185195 | 875 cases and 839 controls; ages 57–69 years at baseline (1993–1998); followed through June, 2004; USA | Nested case-control in Women’s Health Initiative cohort | CRP, leptin, adiponectin, resistin, IL-6, TNF-α, PAI-1, HGF |
| 10 | 22 | Guo, 2015 | 26001129 | 13 prospective studies involving a total of 4,724 cases (n = 403,836); published 2005–2014 |
Meta-analysis | CRP |
| 11 | 33 |
Kabat, 2016 |
26317383 | 275 cases (n = 5,287); 50–79 years at baseline (1993–1998); median follow-up of 11.4 years; USA | Prospective cohort study in the Women’s Health Initiative | Fibrinogen, factor VII antigen activity, factor VII concentration |
| 12 | 34 | Nelson, 2017 | 28292922 | 1114 cases (n = 17,841); 50–79 years at baseline (1993–1998); mean follow-up of 13.6 years; USA | Prospective cohort study in the Women’s Health Initiative | hsCRP |
| 13 | 35 | Tobias, 2018 | 28641369 | 1497 cases (n = 27,071); mean age of 54.5 years at baseline (1992–1995); median follow-up of 19 years; USA | Prospective cohort study in the Women’s Health Study | hsCRP, fibrinogen, GlycA, sICAM-1 |
| 14 | 21 | Wang, 2015 | 25994740 | 943 cases and 1,221 controls; ages 43–69 years at baseline (1989–1990); followed through June, 1998; USA | Nested case-control in the Nurses’ Health Study | hsCRP |
| 15 | 21 | Wang, 2015 | 25994740 | 1,919 cases (n = 27,900); mean age of 55.6/54.6 years (cases/non-cases) at baseline (1992–1995); median follow-up of 19 years; USA | Prospective cohort study in the Women’s Health Study | hsCRP |
| 16 | 21 | Wang, 2015 | 25994740 | 11 prospective studies involving a total of 5,371 cases (n = 73,525); published 2006–2015 |
Meta-analysis | CRP |
| 17 | 36 | Wang, 2015 | 25490990 | 87 cases (n = 19,437); mean age of 49.2 years at baseline (2006–2007); followed through December, 2011; China | Prospective cohort study in the Chinese Kailuan Female Cohort | hsCRP |
| 18 | 37 | Wulaningsih, 2015 | 26130675 | 6606 cases (n = 155,179); mean age of 50.3/46.3 years (cases/non-cases) at baseline (1985–1996); mean follow-up of 18.3 years; Sweden | Prospective cohort study in the Apolipoprotein Mortality Risk Study | CRP, WBC count, albumin, haptoglobin |
Notes: EPIC = European Prospective Investigation into Cancer and nutrition; NSHDS = Northern Sweden Health and Disease Study. Unique study # distinguishes the 18 different studies from the 16 publications identified in this review and can be used to cross-reference with Table 1. Citation # corresponds to the reference number of each publication in this review and can be cross-referenced with the Reference list at the end of the paper.