Table 1.
Comparison of the PEVs cargo and their function. Biologically active molecules, receptors, enzymes, chemokines were categorized based on their functions of the PEVs, but there are no discrepancies detailed for some molecules.
| Function or Category Name | ||||||||
|---|---|---|---|---|---|---|---|---|
| Clotting | Enzymes | Adhesion Molecules | Bioactive Lipids | Programmed Cell Death | Growth Factors | Chemokines /Cytokines |
Immune Response | |
|
PEVs
Cargo (Ref) |
TF [52,53,54] |
12-LO [55] |
CD41/61 [56,57,58,59] CD31 [49,59] |
PS [60] |
caspase-3 [58] |
TGF β1 [50] |
CXCR4-(PF-4) [57,61] |
CD 154 [32,62] |
| FVa, FVIII [60,63] |
heparynase [64] |
CD62P [57,59,65,66] |
AA [67,68] |
CD95 [57] |
PDGF bFGF [64] |
IL-1β [69] |
C5b-9 [70] |
|
| PAR-1 [57] |
PDI [71] |
fibrinogen, vWF, vitronectin [65] |
LPA [70] |
caspase-9 [72] |
VEGF [64] |
CCL5, CCL23 [50,73] |
CD55, CD59 [52] |
|
| TFPI [74] |
NADPH oxidase [75] |
CD42a, CD42b [49,59] |
TXA2 [76] |
CX3CR1 [73] |
Factor H [52] | |||