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Interaction of TD-10 and TD-11 with S1’ pocket of MMP-2 (A,B), MMP-9 (C,D) and MMP-7 (E,F), respectively. S1’ pocket residues surfaces are highlighted in purple color and gatekeeper residues of S1’ pocket shown in cyan color. Three histidine residues that coordinate catalytic Zn ion are shown in orange color.
