Table 1.

Overview on tyrosine phosphatases involved in controlling inflammasome activation.

Tyrosine Phosphatase	Target	Effect on Inflammasome Activation	Reference
PTPN22	NLRP3 Tyr861	De-phosphorylates NLRP3 to allow efficient inflammasome activation	[55,64]
PTPN2	JNK, Syk	Inhibits JNK/Syk mediated ASC phosphorylation and subsequent ASC speck formation	[114]
PTPN11 (SHP2)	ANT-1 in mitochondrial wall	Inhibits excessive NLRP3 activation via enhancing mitochondrial stability/preventing mitochondrial cell wall damage	[124,128]
PTP-S2	p53	Dephosphorylates p53 and thereby reduces its stability to prevent (excessive) p53-mediated CASPASE1 gene transcription/caspase-1 protein accumulation and activation	[134,135]