Table 1.
Summary of evidence for the role of PVT1 and miRNAs in promoting colorectal cancer.
| miRNA | Role of PVT1 | Proposed Pathogenesis Pathway | Reference |
|---|---|---|---|
| miRNA-146a | Decreases levels of miRNA-146a. rs13281615 G > A polymorphism on PVT1 and rs2910164 C > G polymorphism on miR-146a leads to favourable prognosis in CRC | PVT1/miRNA146a/COX2 | [150] |
| miRNA-128 | PVT1-214 upregulates Lin28 by competing for miRNA 128. let-7 is downregulated | PVT1-214/Lin28/let-7 axis | [137] |
| miRNA-216a-5p | PVT1 downregulates miRNA-216a-5p and reverses tumour suppressive effect in CRC | PVT1/miRNA-216a-5p/YBX1 axis | [151] |
| miRNA-455 | PVT1 negatively regulates miRNA-455 and upregulates RUNX | RUNX2/PVT1/miRNA-455 regulatory axis | [152] |
| miRNA-214-3p | PVT1 downregulates miRNA-214-3p promoting CRC progression | PVT1/miRNA-214-3p/Insulin Receptor Substrate 1/PI3K/Akt | [153] |
| miRNA-455-5p | rs1252200336 polymorphism in PVT1 with ID/DD genotype leads to worse survival in CRC affecting Han Chinese population | PVT1 suppresses miRNA-455-5p and miR-455-3p | [143] |
| miRNA-30d-5p | PVT1 suppresses miRNA-30d-5p whilst upregulating RUNX2 | PVT1/miRNA-30d-5p/RUNX2 axis | [154] |
| miRNA-26b | PVT1 inhibits miRNA-26b in promoting proliferation and metastases in CRC | PVT1/miRNA-26b | [132] |
| miRNA-145 | PVT1 downregulation via sponging of miRNA-145 promotes CRC metastases | PVT1/miRNA-145 pathway | [155] |
| miRNA-16-5p | PVT1 binds to miR-16-5p to promote cell proliferation, migration and invasion through VEGFA/VEGFR1/AKT pathway in CRC | PVT1-miR-16-5p/VEGFA/VEGFR1/AKT axis | [156] |