Table 1.

KEGG pathways enrichment in the list of host factors interacting with viral proteins for SARS-CoV-2 (a), highly pathogenic hCoVs (b) and all coronaviruses (c)

Kegg pathway (Term)	Count	%	p-value	Fold enrichment	Benjamini p-value
a—Kegg pathways enrichment in SARS-CoV-2 host protein targets (n = 333)
Protein processing in endoplasmic reticulum	13	4	8.80E−05	4	1.70E−02
RNA transport	12	3.7	4.40E−04	3.6	4.10E−02
b—Kegg pathways enrichment in highly pathogenic hCoVs host protein targets (n = 483)
RIG-I-like receptor signaling pathway	14	3	1.30E−07	6.6	3.00E−05
NF-kappa B signaling pathway	13	2.8	1.10E−05	4.9	8.00E−04
RNA transport	19	4.1	4.10E−06	3.6	4.50E−04
Protein processing in endoplasmic reticulum	18	3.9	1.30E−05	3.5	7.20E−04
Epstein-Barr virus infection	13	2.8	3.10E−04	3.5	1.10E−02
Influenza A	18	3.9	1.90E−05	3.4	8.40E−04
Measles	13	2.8	6.80E−04	3.2	2.10E−02
c—Kegg pathways enrichment in Coronaviruses host protein targets (n = 1140)
Ribosome	59	5.4	9.0E−31	5.8	2.3E−28
RIG-I-like receptor signaling pathway	16	1.5	1.60E−04	3.1	5.60E−03
Protein processing in endoplasmic reticulum	37	3.4	5.20E−09	2.9	6.60E−07
RNA transport	33	3	1.00E−06	2.6	6.30E−05
Endocytosis	43	3.9	1.30E−07	2.4	1.10E−05
Spliceosome	24	2.2	1.10E−04	2.4	4.70E−03
Phagosome	26	2.4	1.00E−04	2.3	5.30E−03