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. 2020 Aug 1;21(15):5524. doi: 10.3390/ijms21155524

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Assessment of changes in survival and behavioral performance following MSC injection for experiment #2. (A) Timeline for experiment #2. (A) Kaplan Meier survival curves drawn from (left graph) the time of VCI surgery (day 0; ameroid constrictors bilaterally applied to the CCAs of 5xFAD mice to generate 5xVCI mice) to MEM/MSC injections (day 27) and (right graph) also from the point of MEM/MSC injection (day 0) to the sacrifice time point (day 30). The dotted broken line indicates the survival results for the MSC group. (B) Behavioral tests performed to assess changes in spatial working memory (Y maze, top graph) and motor coordination (Rotarod, bottom graph) before (pre) and after (post) MEM/MSC injections to the C57VCI mice. * p < 0.05 vs. MEM (post); mean ± S.E.M.