Table 1.

Functional and disease classification of proteins released only in CAC secretome in response to atherosclerotic factors. Protein classification was made with Ingenuity Pathway Analysis (IPA) software. The table includes the main categories containing related functions or diseases, predicted activation (↑) or inhibition (↓) according to IPA, number of molecules per category, p-values assigned, and protein names. Legend: up-regulated ↑, down-regulated ↓. EC: Endothelial cell; CV: Cardiovascular.

	Diseases or Functions	Molecules	p-Value	Gene Names
CV System Development	EC Movement	20	1.01 × 10−8	↑APOE, ↑APOH, ↑CDH13, ↑COL18A1, ↑FN1, ↑HSPB1, ↑HSPG2, ↑KNG1, ↑ORM1, ↑SERPINF1, ↑THBS1, ↑THBS2, ↑VTN, ↓G6PD, ↓GPI, ↓HSP90AB1, ↓ITGB2, ↓MARCKS ↓PTPN6, ↓TMSB10
	EC Development	16	4.54 × 10−6	↑APOA1, ↑APOE, ↑APOH, ↑C3, ↑CDH13, ↑COL18A1, ↑F2, ↑FN1, ↑HSPG2, ↑IGHG1, ↑KNG1, ↑SERPINF1, ↑THBS1, ↑VTN, ↓G6PD, ↓HMOX1
	EC Migration	18	7.64 × 10−8	↑APOE, ↑APOH, ↑CDH13, ↑COL18A1, ↑FN1, ↑HSPB1, ↑KNG1, ↑ORM1, ↑SERPINF1, ↑THBS1, ↑VTN, ↓G6PD, ↓GPI, ↓HSP90AB1, ↓ITGB2, ↓MARCKS ↓PTPN6, ↓TMSB10
	Vasculogenesis	37	4.10 × 10−13	↑APOA1, ↑APOE, ↑APOH, ↑C3, ↑C6, ↑CDH13, ↑CFB, ↑COL15A1, ↑COL18A1, ↑F2, ↑FBLN1, ↑FBLN5, ↑FN1, ↑HSPG2, ↑HTRA1, ↑IGFBP7, IGHG1, ↑KNG1, ↑LTBP1, ↑MYH10, ↑ORM1, ↑SERPINF1, ↑TGM2, ↑THBS1, ↑THBS2, ↑TNC, ↑VTN, ↓CAPN1, ↓CYCS, ↓GCLC, ↓GLRX, ↓G6PD, ↓HMOX1, ↓ITGB2, ↓PTPN6, ↓STX7, ↓YARS
	Angiogenesis	41	6.80 × 10−13	↑APOA1, ↑APOE, ↑APOH, ↑C3, ↑C6, ↑CDH13, ↑CFB, ↑COL15A1, ↑COL18A1, ↑EMILIN1, ↑F2, ↑FBLN1, ↑FBLN2, ↑FBLN5, ↑FN1, ↑HSPB1, ↑HSPG2, ↑HTRA1, ↑IGFBP7, ↑IGHG1, ↑KNG1, ↑LTBP1, ↑MYH10, ↑ORM1, ↑SERPINF1, ↑TGM2, ↑THBS1, ↑THBS2, ↑TNC, ↑VTN, ↓CAPN1, ↓CYCS, ↓GCLC, ↓GLRX, ↓G6PD, ↓HMOX1, ↓HSP90AA1, ↓ITGB2, ↓PTPN6, ↓STX7, ↓YARS
Cell Death and survival	Necrosis	92	2.54 × 10−23	↑APOE, ↑APOA1, ↑BGN, ↑C3, ↑C7, ↑C9, ↑CD59, ↑CD5L, ↑CFH, ↑CLU, ↑COL6A1, ↑COL18A1, ↑EFEMP1, ↑F2, ↑FBLN1, ↑FMOD, ↑FN1, ↑HIST1H2BO, ↑HSPB1, ↑HTRA1, ↑IGFBP7, ↑IGHG1, ↑IGHM, ↑KNG1, ↑LMNA, ↑LTBP1, ↑LUM, ↑MYH10, ↑MYH11, ↑PDLIM7, ↑POSTN, ↑SERPINF1, ↑SOD3, ↑SRI, ↑THBS1, ↑TNC, ↑THBS2, ↑TGM2, ↑TPM1, ↑TTR, ↑VCAN, ↑VTN, ↓ALDH1A1, ↓ADH5, ↓AP2A2, ↓AP2M1, ↓ARCN1, ↓BCAP31, ↓CAPN1, ↓CAST, ↓CCT5, ↓CCT6A, ↓CLTC, ↓CSTB, ↓CYCS, ↓DYNC1H1, ↓G6PD, ↓GCLC, ↓GLRX, ↓GNAI2, ↓GPI, ↓HMOX1, ↓HSP90AA1, ↓HSP90AB1, ↓IDH2, ↓ITGB2, ↓LGMN, ↓LYN, ↓MVP, ↓NAMPT, ↓PSMB1, ↓PSMC1, ↓PNP, ↓PSMC6, ↓PTPN6, ↓PTPRC, ↓PYCARD, ↓RACK 1, ↓RPL10, ↓RPL9, ↓RPL34, ↓RPS13, ↓SERPINB2, ↓STIP1, ↓SNX1, ↓S100A11, ↓TCP1, ↓TTN, ↓TMSB10, ↓TUFM, ↓UBE2L3, ↓YARS
	Apoptosis	84	2.10 × 10−18	↑APOA1, ↑APOE, ↑BGN, ↑C3, ↑C6, ↑CD59, ↑CD5L, ↑CLU, ↑COL18A1, ↑EFEMP1, ↑F2, ↑FBLN1, ↑FBN1, ↑FMOD, ↑FN1, ↑HTRA1, ↑HSPB1, ↑HSPG2, ↑IGFBP7, ↑IGHG1, ↑IGHM, ↑KNG1, ↑LMNA, ↑LTBP1, ↑LUM, ↑MYH10, ↑MYH11, ↑PDLIM7, ↑VCAN, ↑TTR, ↑SRI, ↑CFH, ↑TPM1, ↑SERPINF1, ↑SOD3, ↑TGM2, ↑THBS1, ↑THBS2, ↑TNC, ↑VCL, ↑VTN, ↓ADH5, ↓ALDH1A1, ↓AP2A2, ↓AP2M1, ↓ATOX1, ↓BASP1, ↓BCAP31, ↓CANX, ↓CAPN1, ↓CAST, ↓CLTC, ↓CSTB, ↓CYCS, ↓DYNC1H1, ↓GCLC, ↓GLRX, ↓GNAI2, ↓G6PD, ↓GPI, ↓HMOX1, ↓HSP90AA1, ↓HSP90AB1, ↓ITGB2, ↓LGMN, ↓LYN, ↓MVP, ↓NAMPT, ↓PSMB1, ↓PTPN6, ↓PTPRC, ↓PYCARD, ↓PNP, ↓RACK1, ↓RPL10, ↓RRBP1, ↓S100A11, ↓SERPINB1, ↓SNX1, ↓STIP1, ↓TCP1, ↓TMSB10, ↓TTN, ↓YARS
CV Disease	Atherosclerotic Lesion	11	1.13 × 10−6	↑APOA1, ↑APOE, ↑CD59, ↑COL18A1, ↑FN1, ↑HSPG2, ↑IGHG1, ↑LPA, ↑THBS1, ↑VCAN, ↓HMOX1
	Vascular Lesion	16	7.59 × 10−9	↑APOA1, ↑APOE, ↑CD59, ↑COL18A1, ↑FBN1, ↑FN1, ↑HSPG2, ↑IGFBP7, ↑IGHG1, ↑LPA, ↑MYH11, ↑THBS1, ↑VCAN, ↓HMOX1, ↓PTPRC, ↓RRBP1
Inflammatory response		38	9.27 × 10−14	↑APOA1, ↑APOE, ↑APOH, ↑C3, ↑C6, ↑CFH, ↑COL18A1, ↑F2, ↑FN1, ↑HSPB1, ↑HSPG2, ↑IGHG1, ↑IGHM, ↑KNG1, ↑LPA, ↑LTBP1, ↑LUM, ↑ORM1, ↑PGLYRP2, ↑SERPINF1, ↑SOD3, ↑TGM2, ↑THBS1, ↑THBS2, ↑TNC, ↑VTN, ↓GNAI2, ↓HEBP1, ↓HMOX1, ↓ITGB2, ↓LGMN, ↓LYN, ↓PPIB, ↓PTPN6, ↓PYCARD, ↓SERPINB1, ↓TMSB10, ↓YARS