Table 1.
Clinicopathological features of the patient cohort with OPSCC (N = 171).
| Risk Factors | All | HPV-Related | HPV-Negative | p | ||||
|---|---|---|---|---|---|---|---|---|
| (n = 171) | 100% | (n = 32) | 19% | (n = 138) | 81% | |||
| Nicotine | never | 27 | 16% | 13 | 42% | 13 | 9% | <0.001 |
| former/current | 142 | 84% | 18 | 58% | 124 | 91% | ||
| Alcohol | ≤ 2 drinks/day | 75 | 56% | 27 | 96% | 47 | 45% | <0.001 a |
| > 2 drinks/day | 58 | 44% | 1 | 4% | 57 | 55% | ||
| Age | young (< 60 years) | 92 | 54% | 18 | 56% | 73 | 53% | 0.732 |
| old (≥ 60 years) | 79 | 46% | 14 | 44% | 65 | 47% | ||
| Gender | male | 139 | 81% | 26 | 81% | 113 | 82% | 0.933 |
| female | 32 | 19% | 6 | 19% | 25 | 18% | ||
| ECOG | healthy (0-1) | 118 | 69% | 23 | 72% | 94 | 69% | 0.719 |
| sick (2-4) | 52 | 31% | 9 | 28% | 43 | 31% | ||
| Tumor characteristics | ||||||||
| Localization | tonsil | 90 | 53% | 23 | 72% | 66 | 48% | 0.014 |
| other than tonsil | 81 | 47% | 9 | 28% | 72 | 52% | ||
| Grading | low (G1-2) | 66 | 48% | 11 | 42% | 55 | 50% | 0.506 |
| high (G3-4) | 71 | 52% | 15 | 58% | 56 | 50% | ||
| UICC stages | I - III | 64 | 38% | 12 | 38% | 52 | 38% | 0.939 |
| > III | 105 | 62% | 20 | 62% | 84 | 62% | ||
| T-stage | T1-3 | 129 | 76% | 26 | 81% | 102 | 75% | 0.455 |
| T> 3 | 40 | 24% | 6 | 19% | 34 | 25% | ||
| N-stage | N0 | 52 | 31% | 7 | 22% | 45 | 33% | 0.208 |
| N+ | 116 | 69% | 25 | 78% | 90 | 67% | ||
| M-stage | M0 | 157 | 95% | 29 | 97% | 127 | 95% | 0.664 a |
| M+ | 8 | 5% | 1 | 3% | 7 | 5% | ||
| Recurrence | no | 142 | 83% | 31 | 97% | 111 | 80% | 0.031 a |
| yes | 29 | 17% | 1 | 3% | 27 | 20% | ||
p-values calculated by Pearson’s chi-square test, asymptotic or a Fisher´s exact test, each two-sided, significant p-values (p ≤ 0.05) in bold.