. 2020 Jul 23;21(15):5228. doi: 10.3390/ijms21155228

Table 2.

Relation of PD-L1 (tumor cells and macrophages), MHC I expression and CD8 expression according to each other in the whole cohort and according to HPV-status (n = 171).

			PD-L1 Expression (Tumor Cells)				PD-L1 Expression (Macrophages)					MHC I Expression					CD8 Expression
		yes		no		p	yes		no		p	yes		no		p	yes		no		p
All		64	41%	93	59%		29	19%	130	81%		99	67%	49	33%		42	73%	113	27%
PD-L1 Expression (tumor cells)	yes						14	22%	49	78%	0.370	44	75%	15	25%	0.064	28	46%	33	54%	<0.001
	no						15	16%	76	84%		47	59%	32	41%		9	11%	73	89%
PD-L1 Expression (macrophages)	yes											17	68%	8	32%	0.898	13	48%	14	52%	0.005
	no		39%		61%							76	67%	38	33%		26	22%	93	78%
MHC I Expression	yes																25	26%	70	74%	0.718
	no																14	29%	34	71%
HPV-association	yes	22	73%	8	27%	<0.001	8	27%	22	73%	0.191	15	50%	15	50%	0.028	19	61%	12	39%	<0.001
	no	42	33%	84	67%		21	16%	107	84%		84	71%	34	29%		23	19%	101	81%

											p^b					p^b					p^b
HPV-related OPSCC
PD-L1 Expression (tumor cells)	yes						6	27%	16	73%	1.000	12	60%	8	40%	0.209	16	76%	5	24%	0.028
	no						2	25%	6	75%		2	25%	6	75%		2	25%	6	75%
PD-L1 Expression (macrophages)	yes											3	43%	4	57%	1.000	7	88%	1	12%	0.110
	no											11	52%	10	48%		11	52%	10	48%
MHC I Expression	yes																12	80%	3	20%	0.060
	no																6	40%	9	60%

											p					p					p
HPV-negative OPSCC
PD-L1 Expression (tumor cells)	yes						8	20%	33	80%	0.611	8	20%	33	80%	0.041	12	30%	28	70%	0.005
	no						13	16%	69	84%		13	16%	69	84%		7	9%	67	91%
PD-L1 Expression (macrophages)	yes											14	18%	65	82%	0.582^b	6	29%	15	71%	0.091
	no											4	12%	28	88%		13	14%	83	86%
MHC I Expression	yes																13	16%	67	84%	0.321
	no																8	24%	25	76%

p-values calculated by Pearson´s chi-square test, asymptotic or ^b Fisher´s exact test, each two-sided, significant p-values (p ≤ 0.05) in bold.