Table 3.
Univariate and multivariate survival analysis according to risk factors and tumor characteristics (n = 171).
| Univariate | Multivariate | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | HR | CI | p a | HR | CI | p b | |||||
| Risk factors/tumor characteristics | Lower | Upper | Lower | Upper | |||||||
| PD-L1 Expression (tumor cells) |
no | 93 | 1 | <0.001 | n.s. | ||||||
| yes | 64 | 0.409 | 0.255 | 0.657 | |||||||
| PD-L1 Expression (macrophages) |
no | 130 | 1 | 0.532 | |||||||
| yes | 29 | 0.837 | 0.480 | 1.461 | |||||||
| CD8 Expression | no | 113 | 1 | <0.001 | 3.539 | 1.803 | 6.945 | <0.001 | |||
| yes | 42 | 0.295 | 0.156 | 0.559 | |||||||
| MHC I Expression | no | 49 | 1 | 0.930 | |||||||
| yes | 99 | 0.979 | 0.604 | 1.585 | |||||||
| HPV | HPV-negative | 138 | 1 | 0.001 | n.s. | ||||||
| HPV-related | 32 | 0.270 | 0.125 | 0.585 | |||||||
| Age | young (<60 years) | 92 | 1 | 0.016 | n.s. | ||||||
| old (≥60 years) | 79 | 1.654 | 1.099 | 2.487 | |||||||
| ECOG | healthy (0–1) | 118 | 1 | <0.001 | 0.231 | 0.144 | 0.372 | <0.001 | |||
| sick (2–4) | 52 | 3.386 | 2.233 | 5.134 | |||||||
| UICC7 stages | I-III | 64 | 1 | 0.015 | n.s. | ||||||
| >III | 105 | 0.572 | 0.364 | 0.897 | |||||||
| HPV-related OPSCC | |||||||||||
| PD-L1 Expression (tumor cells) |
no | 8 | 1 | 0.739 | n.s. | ||||||
| yes | 22 | 1.246 | 0.242 | 6.340 | |||||||
| PD-L1 Expression (macrophages) |
no | 22 | 1 | 0.306 | |||||||
| yes | 8 | 35.342 | 0.038 | 32725.7 | |||||||
| CD8 Expression | no | 12 | 1 | 0.047 | 15.099 | 2.231 | 102.2 | 0.005 | |||
| yes | 19 | 5.298 | 1.022 | 27.46 | |||||||
| MHC I Expression | no | 15 | 1 | 0.553 | |||||||
| yes | 15 | 1.573 | 0.352 | 7.042 | |||||||
| Age | young (<60 years) | 18 | 1 | 0.117 | |||||||
| old (≥60 years) | 14 | 3.718 | 0.720 | 19.187 | |||||||
| ECOG | healthy (0-1) | 23 | 1 | 0.321 | n.s. | ||||||
| sick (2-4) | 9 | 0.469 | 0.105 | 2.096 | |||||||
| UICC7 stages | I-III | 12 | 1 | 0.213 | n.s. | ||||||
| >III | 20 | 0.260 | 0.031 | 2.162 | |||||||
| HPV-negative OPSCC | |||||||||||
| PD-L1 Expression (tumor cells) |
no | 84 | 1 | 0.004 | 1.803 | 1.024 | 3.175 | 0.041 | |||
| yes | 42 | 2.139 | 1.247 | 3.593 | |||||||
| PD-L1 Expression (macrophages) |
no | 107 | 1 | 0.566 | |||||||
| yes | 21 | 0.848 | 0.483 | 1.489 | |||||||
| CD8 Expression | no | 101 | 1 | 0.021 | n.s. | ||||||
| yes | 23 | 2.268 | 1.135 | 4.603 | |||||||
| MHC I Expression | no | 34 | 1 | 0.673 | |||||||
| yes | 84 | 1.118 | 0.666 | 1.879 | |||||||
| Age | young (<60 years) | 73 | 1 | 0.052 | |||||||
| old (≥60 years) | 65 | 1.526 | 0.996 | 2.337 | |||||||
| ECOG | healthy (0-1) | 94 | 1 | <0.001 | 0.231 | 0.137 | 0.338 | <0.001 | |||
| sick (2-4) | 43 | 0.245 | 0.157 | 0.380 | |||||||
| UICC7 stages | I-III | 52 | 1 | 0.023 | n.s. | ||||||
| >III | 84 | 0.583 | 0.336 | 0.927 | |||||||
HR hazard ratios estimated by Cox proportional-hazards models; CI 95% confidence interval. a p-values calculated by Log Rank (Mantel-Cox) test; univariate; p < 0.05 in bold; N/A: not applicable. b p-values estimated by Cox proportional-hazards models, uni- and multivariate; p < 0.05 in bold.