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. 2020 Feb 27;11(4):919–928. doi: 10.1002/jcsm.12562

Figure 2.

Figure 2

Associations between stable (solid circles) or gain in SMM (open circles) vs. loss of SMM (reference) and change in global health status and functional subscales of HRQoL, for both CAIRO3 arms combined or stratified by treatment arm in case of a significant interaction (n = 221). Results from a multivariable linear regression analysis, which highlight the change in HRQoL scores for patients with stable SMM and patients who gained SMM. Grey zones show the cut‐off for clinically relevant (i.e. ≥10 points) changes. Models were adjusted for age, sex, treatment arm, World Health Organization performance status, time to PD1, LDH at randomization, previous adjuvant chemotherapy, response to induction treatment, and hospital. Treatment arm was taken out of the model when stratified on treatment arm. This stratification is based on the relative goodness of fit (AICc) of the model with vs. without the interaction terms. Change scores are shown as means with 95% confidence interval. Confidence intervals not including 0 (P < .05) are considered statistically significant. HRQoL, health‐related quality of life; LDH, lactate dehydrogenase; PD1, first progression of disease; SMM, skeletal muscle mass.