Figure 5.

Structures of protease in complexes with its substrate and inhibitors. (a) The structure of ZIKV protein in complex with its substrate consisting of Thr–Gly–Lys–Arg (PDB access code 5GJ4); (b) A Co-crystal structure of ZIKV protease in complex with a di-peptidic inhibitor (PDB access code 5H6V). This inhibitor exhibited a half maximal inhibitory concentration (IC₅₀) of 208 nM [118]; (c) A Co-crystal structure of ZIKV protease in complex with a peptidic inhibitor which exhibited a IC₅₀ of 1.6 µM (PDB access code 5ZOB). All the structures are shown in the same orientation. The NS2B cofactor region and NS3 protease domain are shown in orange and blue, respectively. The peptide and inhibitors are shown as green sticks.