Table 3.
Change between Visits 0 and 3 evaluation in hand‐held myometry assessments in symptomatic‐treated and pre‐symptomatic late‐onset Pompe disease patients
| Test | Symptomatic treated patients n = 22 | Pre‐symptomatic patients n = 9 | ||||||
|---|---|---|---|---|---|---|---|---|
| Visit 0 | Visit 3 | p | SRM | Visit 0 | Visit 3 | p | SRM | |
| Neck flexion | 7.3 ± 5.3 | 8.1 ± 6.1 | 0.1 | 0.15 | 15.5 ± 5.7 | 15.1 ± 6.7 | 0.2 | −0.05 |
| Shoulder abduction | 23.2 ± 10.3 | 22.4 ± 10.2 | 0.52 | −0.12 | 27.6 ± 9.7 | 27.7 ± 6.7 | 0.98 | 0.01 |
| Shoulder adduction | 15.4 ± 10.3 | 16.2 ± 2.2 | 0.37 | 0.14 | 26.5 ± 8.7 | 29.9 ± 7.8 | 0.02 | 0.37 |
| Elbow flexion | 25.3 ± 12.1 | 22.9 ± 2.3 | 0.06 | −0.38 | 29.7 ± 9.4 | 37.4 ± 7.7 | 0.02 | 0.82 |
| Elbow extension | 19.2 ± 9.9 | 17.8 ± 8.2 | 0.13 | −0.34 | 24.2 ± 7.4 | 26.3 ± 6.2 | 0.22 | 0.41 |
| Hip flexion | 21.4 ± 13.8 | 17.1 ± 12.7 | 0.007 | −0.61 | 33.9 ± 11.9 | 32.5 ± 12.3 | 0.46 | −0.5 |
| Hip extension | 11.3 ± 9.1 | 8.7 ± 8.9 | 0.001 | −0.76 | 33.2 ± 25.1 | 35.1 ± 8.1 | 0.06 | 0.19 |
| Hip abduction | 18.3 ± 12.1 | 14.6 ± 10.9 | 0.005 | −0.63 | 33.4 ± 17.7 | 30.3 ± 10.7 | 0.46 | −0.24 |
| Hip adduction | 11.5 ± 7.3 | 8.8 ± 6.3 | 0.001 | −0.76 | 20.8 ± 6.3 | 19.8 ± 5.7 | 0.27 | −0.42 |
| Knee extension | 33.6 ± 19.8 | 28.7 ± 16.4 | 0.01 | −0.54 | 48.1 ± 15.7 | 47.1 ± 11.5 | 0.88 | −0.06 |
| Knee flexion | 20.1 ± 14.2 | 19.1 ± 11.4 | 0.31 | −0.18 | 35.2 ± 13.2 | 34.7 ± 8.2 | 0.91 | −0.04 |
Mean value and standard deviation are shown. Greenhouse–Geisser test analysing the data from Visits 1, 2, 3 and 4 was used to find out whether the differences observed were statistically significant, and p values are shown. All units are expressed as kilogrammes.
SRM, standardized response mean.
Bold emphasis mean statistical significance