Figure 2.

Perfusion of hearts with SA-26 improved postischemic contractile parameters. (A) LVDP at the baseline before drug treatment (B₂₀), during ischemia, and at 10, 20, 30 and 40 min reperfusion (R₁₀, R₂₀, R₃₀, and R₄₀). (B) LVDP recovery at 40 min of reperfusion as a percentage of baseline. (C) Rate of contraction (dP/dt max), and (D) rate of relaxation (dP/dt min) at baseline before drug treatment (B₂₀), ischemia, and 10, 20, 30 and 40 min reperfusion (R₁₀, R₂₀, R₃₀, and R₄₀). (E) Heart rate assessed as beats per minute (BPM) in vehicle treated aerobic hearts and hearts subjected to ischemia-reperfusion (IR) injury at the end of reperfusion (R₄₀). (F) Coronary flow rates from vehicle treated aerobic hearts as well as hearts subjected to IR injury assessed post-ischemia. Values represent mean ± SEM; # p < 0.05 vs. Vehicle IR (n = 4–7 per group). LVDP; left ventricular developed pressure.