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. 2020 Jul 30;21(15):5415. doi: 10.3390/ijms21155415

Figure 2.

Figure 2

Apocynin treatment reduces NADPH oxidase activity and oxidative stress in dystrophic mice. (A) Graphs showing the levels of thiobarbituric acid-reactive substances (TBARS), measured as malondialdehyde (MDA) content in plasma, skeletal muscle and heart from Bl10 and mdx mice, treated with the vehicle or apocynin for one month. (B) NADPH oxidase activity, measured as cytochrome-C reduction activity, in cardiac homogenates from BL10 and mdx mice, treated with the vehicle or apocynin. (C) Western blot analysis of the levels of p22 in cardiac homogenates from BL10 and mdx mice, treated with the vehicle or apocynin for one month. The n is indicated in each bar of the graphs. Asterisks *, **, ***, indicate p < 0.05, 0.005 or 0.001 for comparisons the indicated by the brackets, ANOVA followed by Newman–Keuls as post-hoc test.