Figure 8.

NADPH oxidase inhibition reverses cardiac remodeling in dystrophic hearts. (A) Graphs depicting body weight, heart weight and the ratio of heart to body weight in control (BL10) and mdx mice, treated with the vehicle or apocynin for one month. (B) Images of hematoxylin and eosin staining for the hearts of 10-month-old control (BL10) and mdx mice treated or not with apocynin, each image representative of 5 hearts. The bar indicates 50 µm. (C) Analysis of fibrosis by Masson’s trichrome staining. L, longitudinal sections, T, transverse sections. *, p < 0.05, ** p < 0.01, *** p < 0.001 for the comparisons indicated by the brackets using ANOVA with Newman–Keuls as post-hoc test. The n for each group is indicated inside each bar of the graphs.