Figure 7.

RyR2 phosphorylation sites. Depiction of the three phosphorylation sites targeted by several kinases on RyR2. S2808 and S2814 are located in the “phosphorylation hotspot”, an exposed protruding epitope on RyR2. There may still be sites to be discovered here (i.e., S2811). S2030 is shown as separate from the hotspot. These sites may work independently or together by differential regulation of PKA and CaMKII. The effect on channel gating may be direct or indirect via interaction with classical Ca²⁺ activation sites. Reproduced with permission from ref (82). Copyright 2014 Camors et al.